These are the steps that worked for me:

1. I installed subversion, the MySQL Python lib and python-devel via yast.
2. I checked out the up to date django version via svn into /opt.
3. I ran “sudo python setup.py install” from the trunk directory.
4. I added “PYTHONPATH = djangoProjectDirectory” to my bash configuration (exchange djangoProjectDirectory with the path to your project directory).
5. For the integration of django into Apache I needed to enable mod_env.
6. According to the django mod_python site, I created a snippet I need for the integration into Apache. This snippet looks like this:#Map global URL /media to media folder of django's admin page
Alias /media /opt/trunk/django/contrib/admin/media
<Directory /opt/trunk/django/contrib/admin/media>
Order allow,deny
Allow from all
</Directory>
#add django project itself (repeat so for each additional django project)
<Location "/mysite/">
SetHandler python-program
PythonHandler django.core.handlers.modpython
SetEnv DJANGO_SETTINGS_MODULE mysite.settings
PythonOption django.root /mysite
PythonDebug On
</Location>
7. I stored this snippet in a separate config file called django.conf into the folder /etc/apache2/conf.d/ from which all files are automatically loaded whenever Apache starts.
8. Restart Apache.
9. Go to http://your-domain.com/mysite or http://your-domain.com/mysite/admin (as you might have guessed already, exchange your-domain.com with your domain)

Done.

I put the snippet I need for Django into a separate config file called django.conf into the folder /etc/apache2/conf.d/ from which all files are automatically loaded whenever Apache starts.

Everytime I wanted to start my Apache it said
Syntax error on line 6 of /etc/apache2/conf.d/django.conf:
Invalid command 'SetEnv', perhaps misspelled or defined by a module not included in the server configuration

This seems to be a problem with the Apache configuration of OpenSUSE as mod_env which provides the SetEnv directive is installed but disabled.

Solution:

1. Start yast (from the command line)
2. Select “Network Services”
3. Select “HTTP Server”
4. Select “Server Modules”
5. Select “Network Services”
6. Scroll to “env”
7. Select “Toggle Status”
8. Select “Finish”

Done.